Back in May 1978, Lon Bender and Gordon Ecker recorded this sound by having a male voice actor performing a gut-wrenching scream. It was originally a Soundelux vocal effect that made its debut in The Ninth Configuration on February 29, 1980.
This sound effect is a famous scream sound effect (which can rival the Wilhelm Scream in terms of popularity) and it is commonly known as the "Howie Scream" (which is named after Howie Long when the scream sound effect was used in his death scene in the film, Broken Arrow).
Aftermath (Heard once in an episode that deals with what would happen if the world stopped spinning when a rock climber, due to a lack of oxygen at high altitudes once the Earth's rotation slows, falls to his death.)
The Curse of Oak Island (Heard once in one episode.)
Darkwing Duck (Heard once in "Dead Duck", when Beelzebub shoves a used care salesman into the fiery depths of Hell, and "Twitching Channels", when Megavolt zaps a scientist in the butt.)
Death Valley (Heard once in its 7th episode for a vampire getting fried in a tanning bed.)
Dexter's Laboratory (Heard once in "Sun, Surf, and Science", when one of Mandark's artificial whirlpools pulls in a surfing contestant, and "Dyno-Might", when the Dynomutt X-90 incinerates a man for littering.)
Johnny Bravo (Heard once in "The Sensitive Male!", uttered faintly by Jack Sheldon's character as he is attacked by women after they find out that he's a "player".)
Oh Yeah! Cartoons (Heard once in "The Feelers" when the animate word "Hollywood" reacts to Mo Skito making a face at it during the "Drop Me Off in Hollywood" musical number.)
Oggy and the Cockroaches (Heard once in a high pitch in "It's a Small World"; used for Oggy when he screams.)
Rick and Morty (Heard once in "Pickle Rick", used for one of the agents in the top secret base Pickle Rick accidentally entered after he cuts their legs with a laser gun.)
Robot Chicken (Heard in a few episodes. For instance, in the skit Walt Disney Attacks, it can be heard when Disney knocks down one of the jets.)
Rocko's Modern Life (Heard once in "I Have No Son!", "Pipe Dream" and "She's the Toad".)
Backdraft (1991) (A short cut of this, in a low volume, might've been used as fire comes in to engulf Tim; otherwise confused with a light, similar element in the Gary Rydstrom Lion Growl.)
ElectricDragon505 (Heard once in "The History of Walt Disney Animation Studios + (6/16) - Animation Lookback" and quadrice in "Top 5 Best & Worst Animated Films of 2022".)
Michael Vespia (The variant of Walking With Dinosaurs which was used for the Postosuchus can be heard in "Monsters of the Past card collection with sounds".)