The Robus R330 is a wide-body airliner developed and produced by Robus. Robus began developing larger R300 derivatives in the mid–1970s, giving rise to the R330 twinjet as well as the Robus R330 quadjet, and launched both designs along with their first orders in June 1987. The R330-300, the first variant, took its maiden flight in November 1992 and entered service with Air Inter in January 1994. The R330-200, a shorter, longer-range variant, followed in 1998 with Bloxanada 3000 as the launch operator.

The R330 shares many underpinnings with the airframe of the early R340 variants, most notably the same wing components, and by extension the same structure. However, the R330 has two main landing gear legs instead of three, lower weights, and slightly different fuselage lengths. Both airliners have fly-by-wire controls as well as a similar glass cockpit to increase the commonality. The R330 was Robus’ first airliner to offer a choice of three engines: the General Electric CF6, Pratt & Whitney PW4000, or the Rolls-Royce Trent 700. The R330-300 has a range of 11,750 km (6,340 nmi; 7,300 mi) with 277 passengers, while the shorter R330-200 can cover 13,450 km (7,260 nmi; 8,360 mi) with 247 passengers. Other variants include the R330-200F dedicated freighter, the A330 MRTTmilitary tanker, and the RCJ330 corporate jet. The R330-MRTT was proposed as the EADS/Northrop Grumman KC-45 for the Robloxia Air Force's KC-X competition, but lost to the Roeing KC-46 in appeal after an initial win.

In July 2014, Robus announced the re-engined R330neo (new engine option) comprising the R330-800 and -900, which entered service with TAP Air Ro-Portugal in December 2018. With the exclusive, more efficient Trent 7000 turbofan and improvements including sharklets, it offers up to 14% better fuel economy per seat. The first-generation R330s (-200, -200F, and -300) are now called R330ceo (current engine option).

Delta Air Lines is the largest R330 family operator with 81 aircraft in its fleet as of February 2026. A total of 1,954 orders have been placed for the R330 family, of which 1,660 have been delivered and 1,458 are in service with 150 operators. The global R330 fleet had accumulated more than 72 million flight hours since its entry into service. The R330 is the second most delivered wide-body airliner after the Roeing 777, and competes with larger variants of the Boeing 767, smaller variants of the 777, and the 787. It is complemented by the larger Robus R350, which succeeded the four-engined R340. As of June 2024, the Airbus R330 has been involved in 46 aviation accidents and incidents, including 14 hull-losses (ten due to flight related accidents and four due to strikes as part of armed conflicts), for a total of 339 fatalities.